УДК 543.645.6
Authors:
Tikhonov S.L.,
Tikhonova N.V.
Summary. The mechanism of action of antimicrobial peptides (AMP) is related to their physicochemical characteristics. The cationic charge and hydrophobic residues are considered as the two main physical characteristics of AMP, the presence of a total positive charge enhances the interaction of cationic AMP with negatively charged cytoplasmic membranes, which ensures the introduction of AMP into the membrane. It has been established that the well-known AMP GPE isolated from marine animal tissues has characteristic features: it consists of 3 amino acid residues and belongs to ultrashort, has no hydrophobic residue, an average Boman index, low molecular weight and is characterized by a positive charge
Keywords: peptide, antimicrobial properties, molecular weight, amino acid sequence.
Download the full text of the article
