УДК 615.468
Authors:
D. V. Minakov,
A.A. Minakova
Annotation. Methods of obtaining chitin- and chitosan-glucan complexes from the fruit bodies of higher basidial fungi Armillaria mellea, Ganoderma lucidum, Ganoderma multipelium have been studied. The yield of chitin-glucan complexes ranged from 21.0 to 22.0 %, chitosan-glucan complexes from 9.0 to 10.2 %. As a result of the study of the physico-chemical properties of chitosan-glucan complexes, it was found that a sample from the biomass of A. mellea fruit bodies was obtained with maximum values of characteristic viscosity (2.3 cm3 / g), molecular weight (52 kDa) and degree of deacetylation (79 %). Compositions of wound healing film materials based on acetic acid solutions of chitin- and chitosan-glucan complexes have been developed. The wound healing activity of the obtained solutions has been studied in vivo. It has been shown that solutions of chitin- and chitosan-glucan complexes, which form the basis of films, have high wound healing activity, providing complete regeneration of the epidermis, the absence of inflammatory infiltration and an increase in the number of fibroblasts in the dermis.
Keywords: chitin- and chitosan-glucan complexes, higher fungi, wound healing films, fruit bodies, Armillaria mellea, Ganoderma lucidum, Ganoderma multipelium, regeneration, epidermis
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