УДК 577.112, 577.181
Authors:
E. A. Ulitina
S.L. Tikhonov
N.V. Tikhonova
Annotation. An antioxidant peptide with antimicrobial properties has been developed. Databases of APD, DRAMP, Peptide Ranker, EROP-Moscow and PepCalcbiopeptides were used to create and study the physico-chemical characteristics of the peptide. The peptide has the following sequence: GVAPFYWDERHKARAFKPVRKYPG, is bioactive because the level of biological activity according to the Peptide Ranker predictor is 0.675963. The peptide is highly soluble in water, which indirectly indicates its high bioactivity and antioxidant properties. The peptide, according to the APD program, has a total hydrophobic ratio of 33 %, a positive charge of + 4.25, a molar mass of 2876.312 g / mol, molecular formula C136H200N39O31S0, protein binding potential (Boman 8 9 index) is 2.42 kcal / mol, an isoelectric point at 10.63 and can form a spiral, which indicates its antioxidant and antimicrobial properties. The obtained identification data of the developed peptide from the database of antimicrobial peptides DRAMP indicates its antimicrobial properties.
Keywords: peptides, antioxidant properties, antimicrobial activity, amino acid sequence, hydrophobicity, molecular weight, charge
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